Competition between phase interface and activity-induced heterogeneity in nonequilibrium cellular uptake
The dynamic interplay between activity and phase separation is essential to a broad range of physiological functions. Yet a fundamental understanding of the impact of this nonequilibrium physical process on cellular uptake remains elusive. Combining simulations, theory and experimental discussions, here we explore this crucial process by elucidating the nonequilibrium interactions of active particles with phase-separated cell membranes. In stark contrast to the generally cons
Researchers have explored the complex interactions between active particles and phase-separated cell membranes, a process crucial for many physiological functions. Using simulations and theoretical modeling, they discovered that the activity of particles creates significant variations in membrane density and tension, particularly at the boundaries between different membrane domains. This heterogeneity, influenced by the competition between membrane structure and particle activity, critically governs how particles are taken into the cell.
This study provides a foundational understanding of nonequilibrium physical processes at cellular interfaces, which could inform the development of new biotechnological applications like targeted drug delivery.
📌 Kaynak
Bu özet naturecom kaynağından otomatik derlenmiştir. Tamamı için orijinal habere gidin.
Orijinal haberi oku →